Once-daily pantoprazole 40 mg and esomeprazole 40 mg have equivalent overall efficacy in relieving GERD-related symptoms. Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study. Esomeprazole 40 mg provides more effective intragastric acid control than lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg and rabeprazole 20 mg in patients with gastro-oesophageal reflux symptoms.
Eur J Clin Pharmacol. Esomeprazole 20 mg provides more effective intragastric Acid control than maintenance-dose rabeprazole, lansoprazole or pantoprazole in healthy volunteers.
Clin Drug Investig. Effect of esomeprazole 40 mg vs. Reanalysis of intragastric pH results based on updated correction factors for Slimline and Zinetics 24 single-use pH catheters. User Username Password Remember me. Font Size. Notifications View Subscribe. Article Tools Print this article. Indexing metadata. How to cite item. No correlation between healing and symptom relief was seen. The majority of reported adverse events were assessed as "not related" to the study drug.
Protonix or Nexium may be safe to take while pregnant. However, they should only be used if the benefits outweigh the risks. Currently, there are not enough studies to show that Protonix or Nexium is completely safe to use during pregnancy.
Consult a healthcare provider for medical advice on the best treatment for GERD while pregnant. While alcohol is not known to interact with Protonix or Nexium, it can worsen acid reflux and heartburn symptoms in some people. Alcohol use may be safe in moderation while taking Protonix or Nexium, but it is not generally recommended.
The most effective PPI will depend on the condition being treated, the dosage of the PPI, and other medications a person might be taking. The cost of the PPI should also be taken into consideration when determining the most effective option.
Nexium esomeprazole is a proton pump inhibitor. Other proton pump inhibitors include Prilosec omeprazole , Prevacid lansoprazole , Aciphex rabeprazole , and Protonix pantoprazole.
Examples of H2 blockers include Pepcid famotidine , Zantac ranitidine , and Tagamet cimetidine. Nexium is used to treat acid reflux. Discontinuing Nexium treatment earlier than recommended by a healthcare provider may lead to a return of reflux symptoms. Nexium might not work the same for everyone.
If symptoms do not improve with Nexium, other treatment options may be recommended. Skip to main content Search for a topic or drug. Protonix vs. Nexium: Differences, similarities, and which is better for you. By Kristi C. Torres, Pharm. Updated on May.
Top Reads in Drug vs. Toujeo vs Lantus: Main Differences and S Meta-analysis: comparing the efficacy of proton pump inhibitors in short-term use.
Aliment Pharmacol Ther ;— This article attempts to review the literature on this topic. Bob : It is a meta-analysis of 41 studies comparing various PPIs. The authors identified 20 studies of GERD, nine studies of peptic ulcer disease, and 16 studies of Helicobacter pylori therapy. Two studies of esomeprazole Nexium 40 mg versus omeprazole 20 mg found a small difference. The six remaining studies were a hodge-podge group of trials comparing various PPIs at different doses, none of which demonstrated any superiority.
Andrea : All of the studies, except for the two that compared esomeprazole and omeprazole, found that there were no differences among any of the drugs in the treatment of GERD. As for the two studies that suggested esomeprazole was better than omeprazole, the studies were not fair comparisons. Both studies used higher dosages of esomperazole compared with omeprazole. This cannot be considered a true comparison of effectiveness. In the study comparing esomeprazole with omeprazole, esomeprazole did better.
Well, that's no surprise—esomeprazole is the active isomer of omeprazole, and the study authors used a dosage four times that of omeprazole. Breaking this down, they used 40 mg of active drug esomeprazole versus 10 mg of active drug omeprazole the dosage is actually 20 mg, but since omeprazole is a racemic mixture, that is only 10 mg of active drug , and guess what?
The drug not going off patent did better! And who sponsored the study? Astra-Zeneca, the manufacturer. Bob : I knew you would jump on the inappropriate comparison of esomeprazole with omeprazole. Another problem with this comparison is that a true clinical end point is not being measured. But I have the same complaints as I did with the GERD studies regarding the use of unequal dosages and using endoscopic cure rates as the end point.
And do I even have to do the H. Sixteen studies with no differences noted among any PPIs.
0コメント